DESCRIPTION: Amino‑Kojyl Phosphate is a phosphorylated, amino‑functional derivative of kojic acid, engineered for enhanced stability, bioavailability, and dermal penetration. The addition of an amino group and phosphate moiety increases water solubility, reduces oxidative degradation, and improves compatibility with multi‑active brightening systems. It is used as a melanogenesis‑modulating active in advanced cosmetic formulations targeting hyperpigmentation, uneven tone, and photo‑induced discoloration.
MECHANISM OF ACTIVITY:
Amino‑Kojyl Phosphate operates through multi‑pathway melanogenesis interruption, offering a more robust effect than standard kojic acid:
- Tyrosinase Inhibition — Chelates copper ions at the active site of tyrosinase, reducing conversion of L‑tyrosine to L‑DOPA and downstream melanin synthesis.
- Melanosome Transfer Reduction — Downregulates PAR‑2 signaling, limiting melanosome transport from melanocytes to keratinocytes.
- Antioxidant Interference — Scavenges ROS that trigger melanocyte hyperactivity and UV‑induced pigmentation cascades.
- Stabilized Delivery — Phosphate ester improves chemical stability and allows enzymatic cleavage in skin, releasing active kojic derivatives in a controlled manner.
BENEFITS
- Visible brightening of dull skin and reduction of dark spots
- Improved stability compared to kojic acid (less browning, less oxidation).
- Enhanced dermal penetration due to amino functionalization.
- Synergistic compatibility with niacinamide, tranexamic acid, and vitamin C derivatives.
- Reduced irritation potential versus traditional exfoliating brighteners.
- Supports uniform tone and clarity in long‑term use.
- Effective in both leave‑on and wash‑off systems.
APPLICATIONS: Hyperpigmentation Serums, Brightening Creams, Spot‑Correcting Treatments, Post‑inflammatory Pigmentation Care, Chemical Peel Boosters (non‑acidic brightening adjunct), Cleansers and Toners, Sheet Masks and Ampoules
HOW TO USE
INCI: Amino Kojyl Phosphate
Use rate: Typically 1–5% depending on system type and desired efficacy
Solubility: Highly water‑soluble; compatible with hydrophilic phases and cold‑process systems
Optimal pH Stability: pH 4.0–7.0; avoid highly acidic environments that may hydrolyze phosphate ester
Heat Tolerance: Stable up to 70°C in aqueous phase; recommended to add during cool‑down for maximum integrity
Appearance: White to off‑white powder; low odour; non‑hygroscopic.
Storage: Store in airtight container, protected from light and moisture; recommended temperature 15–25°C
This is a cosmetic raw material and is meant for external use only in cosmetic formulations. As with all of our materials, it should not be taken internally. Treasure Actives is not responsible for product compatibility. We advise everyone to test ingredients for performance, compatibility, and safety prior to committing to larger quantities. Keep all products out of reach of children. For more information, please see our terms and conditions page.
