DESCRIPTION: Licochalcone A is a high‑potency anti‑inflammatory and antioxidant chalcone derived from Glycyrrhiza inflata. It is widely used in dermocosmetic formulations for sensitive, reactive, acne‑prone, and redness‑prone skin due to its ability to calm irritation, neutralize free radicals, and support barrier recovery.
MECHANISMS OF ACTION
Anti‑Inflammatory Pathway Modulation: It helps “switch off” the signals that cause visible redness and irritation, making skin feel calmer and more comfortable. Licochalcone A inhibits multiple pro‑inflammatory mediators, including interleukins and prostaglandins, reducing redness, swelling, and irritation.
Antioxidant Defense Activation: Licochalcone A activates antioxidant and detoxifying enzymes, protecting skin cells from oxidative damage such as lipid peroxidation, DNA damage, and protein degradation. It works like a “shield,” neutralizing environmental stressors that age and irritate the skin.
It also protects against:
- UV-induced oxidative stress.
- Blue light (HEVIS)–induced ROS (reactive oxygen species).
Sebum Regulation & Anti‑Acne Support: It helps keep oil levels balanced and reduces the look of angry, red blemishes. Studies indicate that Licochalcone A helps regulate excess sebum production, while its anti‑inflammatory action reduces acne‑related redness and swelling. This also help reduce the appearance of large pores.
Barrier Support & Redness Reduction: It strengthens the skin’s natural defenses, helping it stay hydrated and less reactive. By reducing inflammation and oxidative stress, Licochalcone A indirectly supports:
- Barrier repair
- Reduced transepidermal water loss (TEWL)
- Improved comfort in sensitive skin
BENEFITS
- Visibly reduces redness and irritation.
- Helps calm sensitive and reactive skin.
- Protects skin from environmental stressors, including UV and blue light.
- Supports clearer, healthier-looking skin.
- Helps balance oil and reduce acne-related redness.
- High-purity powder effective at low concentrations
- Skin lightening
SYNERGIES: Works well with niacinamide, salicylic acid, salicylic-soft, ceramides, phytosterol esters, Ocymen solution, Zinc PCA, etc.
APPLICATIONS: Calming creams, Anti-redness serums, Barrier-repair moisturizers, Acne-Prone Skincare for Oil-control moisturizers and Post-acne calming treatments. Sun & Blue Light Protection, SPF boosters and Anti-photoaging serums. Post-Procedure Care for Laser recovery creams and Chemical peel aftercare.
FORMULATION GUIDELINES
| Property | Description |
| INCI | Licochalcone A (and) Propanediol |
| Chemical class | Chalcone-type flavonoid |
| Use rate | 1.0 – 3% (Recommendation: 1.0% for regular products and up to 3% for post-procedure products) |
| pH Stability | 3.5 – 6.5 |
| Temperature Tolerance | Avoid temperatures above 60°C |
| Solubility | Water (May need supension with a gum – test your formula). |
| Appearance | Deep yellow/brownish slightly viscous liquid with characteristic scent. |
| Assay | 1.0% |
| Stability | Stable in emulsions; sensitive to strong UV exposure. Protect finished product from direct light using amber/opaque packaging and minimal light exposure during processing. |
| Storage | Store in a cool, dark and dry place |
This is a cosmetic raw material and is meant for external use only in cosmetic formulations. As with all of our materials, it should not be taken internally. Treasure Actives is not responsible for product compatibility. We advise everyone to test ingredients for performance, compatibility, and safety prior to committing to larger quantities. Keep all products out of reach of children. For more information, please see our terms and conditions page.
