DESCRIPTION: Thiazolyl (more comonly known as Thiamidol) is a novel skin-lightening ingredient with clinical efficacy. Its mechanism of action is via anti-tyrosinase inhibition. Thiamidol is a potent, selective lightening agent in preventing and treating post-inflammatory hyperpigmentation, such as dark spots, melasma sun darkening, etc

According to one research, Thiamidol was applied to a group of people and a control base was applied to another. They were further exposed to UVB radiation. Participants who applied Thiamidol-based products had significantly lighter skin. This study was conducted on 30 participants for 3 weeks.

Another clinical study conducted a double-blinded trial, using Thiamidol for 3 months on 14 participants with acne-related PIH. After 2 weeks of treatment, thiamidol-treated sites were significantly lighter than control sites and improved during the treatment period. The evaluation was done using Mexameter measurements, expert grading, self-grading and clinical photography.

A randomized evaluator-blinded controlled study comparing both efficacy and tolerance of Thiamidol (0.2% twice daily) and Hydroquinone (4.0% at bedtime) on facial melasma for 90 days with sunscreen SPF 60 PPD 20). The melasma improvement achieved using 0.2% Thiamidol did not differ from that of 4% hydroquinone cream. Thiamidol is a suitable option for melasma patients who have a low tolerance towards hydroquinone or have had treatment failure with it.

A Clinical trial on Fitzpatrick V & VI for 12 weeks on 29 participants with acne-related PIH After 12 weeks of treatment. The evaluation used Mexameter measurements, expert grading, self-grading and clinical photography.

RECOMMENDATION

Based on our studies, thiamidol is a potent but selective pigment inhibitor; Our recommendation is to use this active to treat post-inflammatory pigmentation, such as those with acne marks, dark spots, burns, melasma, atopic dermatitis, etc. For best results, this product should be applied both day and night or up to 3 times daily. To potentiate results and/or overall skin lightening, combine it with other skin lighteners. The best results were seen at 12 weeks.

Please note: This active is patented by Eucerin – This means that you cannot name this ingredient as the active used to achieve skin-lightening efficacy in your product claims. You cannot also use the name Thiamidol as it is patented.

To prevent oxidation, please add Activ-Shield and/or Active lipid shield to help inhibit discolouration. Use in an airtight packaging is also beneficial.

FEATURES

• Effective Tyrosinase inhibition
• Selective on post-inflammatory pigmentation.
• Effective at preventing sun-induced skin darkening.
• No adverse effects have been noted with the recommended concentration.
• Effective in lightening for Acne-Marks
• Effective on dyspigmentation (hypopigmentation and hyperpigmentation).
• Evens out the skin tone
• Best combined with other products
• For optimal results, increase application frequency.

APPLICATIONS: In lotions, serums, creams, masks, peels, etc. Very good for spot treatment, products used to prep skin peel and after skin peeling, etc

INCI: Isobutylamido Thiazolyl Resorcinol

Use rate: 0.1 – 0.5 Recommended 0.2 – 0.5% for general skin lightening with other actives, 0.5 for spot lightening and higher efficacy.

Solubility: Glycols

pH Stability: 4.0 – 5.5

Temperature Sensitivity: Avoid temperatures above 80°C. If heating to 80°C, cool immediately.

Appearance: Light coloured powder

Storage: Store in a cool, dark, and dry place.

This is a cosmetic raw material and is meant for external use only in cosmetic formulations.  As with all of our materials, it should not be taken internally. Treasure Actives is not responsible for product compatibility. We advise everyone to test ingredients for performance, compatibility, and safety prior to committing to larger quantities. Keep all products out of reach of children. For more information, please see our terms and conditions page.