Wasabi SOD

DESCRIPTION: Wasabi SOD is a high performance antioxidant extract derived from Japanese wasabi. It is naturally rich in superoxide dismutase (SOD)—one of the body’s most powerful defense enzymes. SOD helps neutralize the most aggressive free radicals, protecting the skin from environmental stress, pollution, and premature aging. Wasabi SOD helps keep skin calm, protected, and youthful looking.

MECHANISM OF ACTIVITY

1. Superoxide Radical Neutralization: SOD is the primary enzyme responsible for converting superoxide radicals into less reactive molecules: This reduces oxidative stress at the cellular level and protects:

• Collagen and elastin
• Lipid membranes
• DNA and cellular proteins

2. Anti Inflammatory Pathway Modulation: By reducing oxidative stress, SOD indirectly downregulates:

• NF κB activation
• Pro inflammatory cytokines (IL 6, TNF α)

This results in calmer, less reactive skin.

3. Anti Pollution Defense: Wasabi contains sulfur rich compounds and isothiocyanates that help:

• Reduce oxidative damage from particulate matter (PM2.5)
• Protect keratinocytes from pollution induced stress

4. Support for Skin Barrier Integrity: Oxidative stress weakens the barrier. SOD helps maintain:

• Lipid stability
• Ceramide integrity
• Reduced TEWL (transepidermal water loss)

5. Anti Glycation Support (Indirect): By lowering oxidative load, SOD slows the formation of AGEs (Advanced Glycation End products), helping maintain firmness and elasticity.

RESEARCH

In‑Vitro Data (Typical)

• Superoxide radical reduction: up to 70–90% reduction in ROS in fibroblast cultures
• Collagen protection: up to 30–40% reduction in collagen degradation under oxidative stress
• Lipid peroxidation reduction: up to 50% decrease in MDA formation
• Pollution protection: keratinocytes show significantly reduced oxidative markers when exposed to PM2.5 + Wasabi extract

Ex‑Vivo / In‑Vivo (Typical Supplier Studies)

• Improved skin smoothness after 4 weeks
• Reduced visible redness and irritation
• Enhanced radiance and evenness
• Improved hydration and barrier function

BENEFITS

• Potent enzymatic antioxidant activity
• Reduces oxidative stress markers in vitro
• Protects fibroblasts from ROS‑induced damage
• Helps maintain collagen and elastin integrity
• Reduces inflammatory cytokine expression
• Supports barrier recovery and lipid stability
• Protects against pollution‑induced oxidative stress

• Reduces visible signs of fatigue
• Helps skin look brighter and more even
• Improves firmness and elasticity over time
• Reduces the appearance of fine lines
• Helps calm redness and irritation
• Enhances skin smoothness and suppleness

APPLICATIONS: Anti‑aging serums, Anti‑pollution skincare, Barrier‑repair creams, Sensitive‑skin formulations, Brightening and radiance boosters, Post‑procedure calming products, Men’s skincare (anti‑irritation), Daily protective moisturizers.

Compatibility Notes

• Pair with chelators (e.g., sodium phytate)
• Use antioxidants (vitamin E, ferulic acid) to support stability
• Protect from UV exposure in packaging
• Avoid strong oxidizers or high-concentration AHAs
• Pairs well with vitamin C derivatives, peptides, PPQ Cell-Life, Tetrapeptide-21, Activated Retinol, Ectoin, APQ3-Moist (Glyceryl Glucoside, Glucosaminoglycans (Full Spectrum), Niacinamide PC, ceramide complex, Green tea extract clear, ferulic acid, Alpha lipoic acid, etc

FORMULATION GUIDELINES

This is a cosmetic raw material and is meant for external use only in cosmetic formulations.  As with all of our materials, it should not be taken internally. Treasure Actives is not responsible for product compatibility. We advise everyone to test ingredients for performance, compatibility, and safety prior to committing to larger quantities. Keep all products out of reach of children. For more information, please see our terms and conditions page.